Neuroprotective Agent Resveratrol in Managing Oxidative Stress in Alzheimer’s Disease

Alzheimer’s disease is a multifaceted neurodegenerative disorder characterized by memory loss, brain mass reduction, and the presence of Amyloid β plaques. Oxidative stress, mitochondrial dysfunction, and inflammation are all associated with this disease, and their interconnectivity in causing the development is still being investigated. The accumulation of reactive oxygen and nitrogen species from lipid peroxidation and macromolecule oxidation is thought to be responsible for oxidative stress’s effects. The mitochondrial cascade hypothesis suggests that amyloid beta plaques form due to the loss of mitochondrial function. This leads to abnormal expression of machinery involved with the amyloid precursor protein (APP) and contributes to the pathology of Alzheimer’s disease. Amyloid β accumulation harms synapses and impairs neuronal transmission, causing neuronal pathway deterioration. Recent studies indicate that resveratrol, a polyphenol compound found in several plant species and fruits, may have therapeutic potential in treating Alzheimer’s disease by reducing oxidative stress and plaque pathology. Resveratrol is thought to inhibit several inflammatory and other neurotoxic pathways that serve to cause apoptosis and neuronal communication blockage in the CNS. However, additional research is necessary to fully comprehend the benefits of resveratrol and other polyphenols for Alzheimer’s disease treatment.